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Research of the Division of Biochemistry is focused to understand the molecular principles of membrane dynamics in animal cells. Lipidomic techniques are applied to study the function of lipids and lipid droplets in the pathogenesis of veterinary and human diseases. The Division of Biochemistry currently investigates:

Membrane dynamics of lipid droplets in liver regeneration
adrpI-dic Activation of hepatic stellate cells (HSCs) has been recognized as one of the first steps in liver injury and regeneration. During activation, HSCs transform into myofibroblasts with concomitant loss of their large amounts of lipid droplets (LDs) and production of excessive extracellular matrix. To obtain more insight in the mechanism of LD loss and its role in HSC activation, we investigate the lipid droplet dynamics in primary HSCs. For more information, click here.
Membrane dynamics in host–pathogen interactions
i1 Intracellular pathogens have devised often ingenious strategies to modify the membrane dynamics of host cells, allowing them to divert cellular processes and survive an otherwise hostile environment. Lipids play an important role in cellular signaling, membrane microdomain organization and dynamics, and membrane trafficking. Pathogens take full advantage of the complexity of the lipidome to modulate host cell responses. For more information, click here.
Membrane dynamics during fertilization
i3 Molecules involved in the process of activation of gametes and fertilization are largely unknown. Human and animal infertility is an increasingly important research area and optimized assisted reproductive technologies are economically relevant for veterinary breeding industries. Central topics in this research line are the dynamics in adhesive and fusion properties, molecular composition and architecture of the two gamete’s membranes as well as membrane derived signalling ultimately leading to embryo development. For more information, click here.
Lipidomic projects
3d PCA-Left Our research is also aided by an in house Mass Spectroscopy facility, fully dedicated to the development and application of lipidomic techniques to fundamental, applied, and clinical research. The novel technology of lipid mass spectrometry has revealed that there are thousands of different lipids in animal and human organisms, with a multitude of different functions that are yet to be discovered. For more information, click here.